▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …

▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor
immunosurveillance. Here, we report that melanoma patients with high expression of …

PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal
anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin …

Prostanoids are cyclic, oxygenated products ofω3 andω6 20-and 22-carbon essential fatty
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …

Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …

The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …

Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase
[cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the …

Recent epidemiologic studies have shown a 40–50% reduction in mortality from colorectal
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …

Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and
subsequent downstream synthetases. Two closely related forms of the cyclooxygenase have …