Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our
appreciation for the pathogenic complexity of this disease and the challenges associated …

Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from
autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been …

DIABETES mellitus is simply defined on the basis of hyperglycemia. It is, however, a highly
heterogeneous disease. A major advance was made in the late 1960s when insulin …

OBJECTIVE We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to
predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …

Hormones play key roles in the regulation of animal and plant life histories, particularly in the
timing of transitions between prematurational stages and in the scheduling of reproduction …

Insulin-dependent diabetes mellitus (IDDM) is associated with autoreactivity against GAD
but the diagnostic sensitivity (positivity in disease) and specificity (negativity in health) of …

IA-2 is a 105,847 Da transmembrane protein that belongs to the protein tyrosine
phosphatase family. Immunoperoxidase staining with antibody raised against IA-2 showed …

Type I (insulin-dependent) diabetes mellitus results from destruction of the beta cells of the
islets of Langerhans, usually leading to absolute insulin deficiency. Although some patients …