Background and Purpose—Stroke is a leading cause of disability and death in the United
States, yet limited therapeutic options exist. The need for novel neuroprotective agents has …

Long-term memory is believed to be maintained by persistent modifications of synaptic
transmission within the neural circuits that mediate behavior. Thus, long-term potentiation …

Although endogenous recruitment of adult neural stem cells has been proposed as a
therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that …

Synaptic plasticity is a key mechanism for chronic pain. It occurs at different levels of the
central nervous system, including spinal cord and cortex. Studies have mainly focused on …

Protein kinase M-ζ (PKM-ζ) is a constitutively active form of atypical protein kinase C that is
exclusively expressed in the brain and implicated in the maintenance of long-term …

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term
memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two …

Protein kinase Mζ (PKMζ) is a newly described form of PKC that is necessary and sufficient
for the maintenance of hippocampal long term potentiation (LTP) and the persistence of …

Previously, D 2 dopamine receptors (D 2 DARs) have been shown to undergo G-protein-
coupled receptor kinase phosphorylation in an agonist-specific fashion. We have now …

Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes
a burden on the society. Available treatments help a substantial proportion of patients but …

Direct phosphorylation of GluA1 by PKC controls α‐amino‐3‐hydroxy‐5‐methyl‐isoxazole‐
4‐propionic acid (AMPA) receptor (AMPAR) incorporation into active synapses during long …