Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
Engineering the composition and fate of wild populations with gene drive
BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …
sources of economically important products. They can also destroy crops; wound animals; …
Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility
Background Gene drives based on CRISPR-Cas9 technology are increasingly being
considered as tools for reducing the capacity of mosquito populations to transmit malaria …
considered as tools for reducing the capacity of mosquito populations to transmit malaria …
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population
Engineered gene drives are being explored as a new strategy in the fight against vector-
borne diseases due to their potential for rapidly spreading genetic modifications through a …
borne diseases due to their potential for rapidly spreading genetic modifications through a …
A toxin-antidote CRISPR gene drive system for regional population modification
Engineered gene drives based on a homing mechanism could rapidly spread genetic
alterations through a population. However, such drives face a major obstacle in the form of …
alterations through a population. However, such drives face a major obstacle in the form of …
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of
populations with CRISPR homing gene drives. One proposed solution is using multiple …
populations with CRISPR homing gene drives. One proposed solution is using multiple …
[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …
spread throughout a population. They could potentially be used to modify or suppress pest …
Performance analysis of novel toxin-antidote CRISPR gene drive systems
Background CRISPR gene drive systems allow the rapid spread of a genetic construct
throughout a population. Such systems promise novel strategies for the management of …
throughout a population. Such systems promise novel strategies for the management of …
Gene drive for population genetic control: non-functional resistance and parental effects
Gene drive is a natural process of biased inheritance that, in principle, could be used to
control pest and vector populations. As with any form of pest control, attention should be …
control pest and vector populations. As with any form of pest control, attention should be …
Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework
SE Champer, N Oakes, R Sharma… - PLoS computational …, 2021 - journals.plos.org
Invasive rodent populations pose a threat to biodiversity across the globe. When confronted
with these invaders, native species that evolved independently are often defenseless …
with these invaders, native species that evolved independently are often defenseless …