One of the most fascinating and unusual features of trypanosomatids, parasites that cause
disease in many tropical countries, is their mitochondrial DNA. This genome, known as …

Helicases are ubiquitous enzymes found in all organisms that are necessary for all (or
virtually all) aspects of nucleic acid metabolism. The Pif1 helicase family is a group of 5′→ …

We review and demonstrate how an empirical Bayes method, shrinking a protein's sample
variance towards a pooled estimate, leads to far more powerful and stable inference to …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

Replication of the mammalian mitochondrial DNA (mtDNA) is dependent on the minimal
replisome, consisting of the heterotrimeric mtDNA polymerase (POLG), the hexameric DNA …

Mitochondrial DNA (mtDNA) is an essential multicopy genome, compacted into protein–DNA
clusters called nucleoids. Maintaining an adequate mtDNA copy number is crucial for …

Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the
diversity in mitochondrial genome size and organization in the different eukaryotic …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

Telomeres protect the ends of eukaryotic chromosomes from being recognized and
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …

The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …