Human endogenous retrovirus-K (HML-2): a comprehensive review

M Garcia-Montojo, T Doucet-O'Hare… - Critical reviews in …, 2018 - Taylor & Francis
The human genome contains a large number of retroviral elements acquired over the
process of evolution, some of which are specific to primates. However, as many of these are …

Human endogenous retrovirus K (HML-2) in health and disease

B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

M Manghera, RN Douville - Retrovirology, 2013 - Springer
Humans are symbiotic organisms; our genome is populated with a substantial number of
endogenous retroviruses (ERVs), some remarkably intact, while others are remnants of their …

[HTML][HTML] Human endogenous retroviruses (HERVs) and autoimmune rheumatic disease: is there a link?

N Tugnet, P Rylance, D Roden, M Trela… - The open rheumatology …, 2013 - ncbi.nlm.nih.gov
Autoimmune rheumatic diseases, such as RA and SLE, are caused by genetic, hormonal
and environmental factors. Human Endogenous Retroviruses (HERVs) may be triggers of …

HervD Atlas: a curated knowledgebase of associations between Human endogenous retroviruses and diseases

C Li, Q Qian, C Yan, M Lu, L Li, P Li, Z Fan… - Nucleic Acids …, 2024 - academic.oup.com
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus
infected and integrated into germ cells, comprise∼ 8% of the human genome. These …

Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case–control study

G Mameli, GL Erre, E Caggiu, S Mura… - Clinical & …, 2017 - academic.oup.com
Endogenous retroviruses (HERV) are believed to be pathogenic in several autoimmune
diseases. Among them, HERV-K viruses have been reported recently to be involved in the …

The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity

M Trela, PN Nelson, PB Rylance - Apmis, 2016 - Wiley Online Library
Human Endogenous Retroviruses (HERV s) have been implicated in autoimmune and other
diseases. Molecular mimicry has been postulated as a potential mechanism of …

Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing

B Xue, T Zeng, L Jia, D Yang, SL Lin, LA Sechi… - Retrovirology, 2020 - Springer
Abstract Background Human endogenous retroviruses (HERVs), suspected to be
transposition-defective, may reshape the transcriptional network of the human genome by …

Limitations of current high-throughput sequencing technologies lead to biased expression estimates of endogenous retroviral elements

K Kitsou, A Katzourakis… - NAR Genomics and …, 2024 - academic.oup.com
Human endogenous retroviruses (HERVs), the remnants of ancient germline retroviral
integrations, comprise almost 8% of the human genome. The elucidation of their biological …

The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls

JH Wildschutte, D Ram, R Subramanian, VL Stevens… - Retrovirology, 2014 - Springer
Background Integration of retroviral DNA into a germ cell can result in a provirus that is
transmitted vertically to the host's offspring. In humans, such endogenous retroviruses …