Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

[HTML][HTML] Human tuberculosis and Mycobacterium tuberculosis complex: A review on genetic diversity, pathogenesis and omics approaches in host biomarkers …

RD Kanabalan, LJ Lee, TY Lee, PP Chong… - Microbiological …, 2021 - Elsevier
Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

HR Ramage, LE Connolly, JS Cox - PLoS genetics, 2009 - journals.plos.org
Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial
genomes, are unusually abundant in the major human pathogen Mycobacterium …

Methodological and clinical aspects of the molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria

T Jagielski, A Minias, J van Ingen… - Clinical microbiology …, 2016 - Am Soc Microbiol
Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Genetic diversity of Mycobacterium avium subspecies paratuberculosis and the influence of strain type on infection and pathogenesis: a review

K Stevenson - Veterinary research, 2015 - Springer
Mycobacterium avium subspecies paratuberculosis (Map) is an important pathogen that
causes a chronic, progressive granulomatous enteritis known as Johne's disease or …

Lateral genetic transfer and the construction of genetic exchange communities

E Skippington, MA Ragan - FEMS microbiology reviews, 2011 - academic.oup.com
Lateral genetic transfer (LGT) is a major source of phenotypic innovation among bacteria.
Determinants for antibiotic resistance and other adaptive traits can spread rapidly …

After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection

A Namouchi, X Didelot, U Schöck, B Gicquel… - Genome …, 2012 - genome.cshlp.org
Many of the most virulent bacterial pathogens show low genetic diversity and sexual
isolation. Accordingly, Mycobacterium tuberculosis, the deadliest human pathogen, is …

Evolution of tuberculosis pathogenesis

CS Pepperell - Annual Review of Microbiology, 2022 - annualreviews.org
Mycobacterium tuberculosis is a globally distributed, lethal pathogen of humans. The
virulence armamentarium of M. tuberculosis appears to have been developed on a scaffold …

The mycobacterial cell envelope: a relict from the past or the result of recent evolution?

AT Vincent, S Nyongesa, I Morneau, MB Reed… - Frontiers in …, 2018 - frontiersin.org
Mycobacteria are well known for their taxonomic diversity, their impact on global health, and
for their atypical cell wall and envelope. In addition to a cytoplasmic membrane and a …

The Role of Selection in Shaping Diversity of Natural M. tuberculosis Populations

CS Pepperell, AM Casto, A Kitchen, JM Granka… - PLoS …, 2013 - journals.plos.org
Mycobacterium tuberculosis (M. tb), the cause of tuberculosis (TB), is estimated to infect a
new host every second. While analyses of genetic data from natural populations of M. tb …