B cell memory: building two walls of protection against pathogens
Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …
Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health
Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …
remain numerous globally devastating diseases without fully protective vaccines, particularly …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
L Mesin, A Schiepers, J Ersching, A Barbulescu… - Cell, 2020 - cell.com
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
Regulation of the germinal center response
M Stebegg, SD Kumar, A Silva-Cayetano… - Frontiers in …, 2018 - frontiersin.org
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4+ T cells potentiates type 2 immunity and promotes parasitic helminth expulsion
CJ Oliphant, YY Hwang, JA Walker, M Salimi, SH Wong… - Immunity, 2014 - cell.com
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective
immunity to helminth infection and detrimentally during allergy and asthma. Using two …
immunity to helminth infection and detrimentally during allergy and asthma. Using two …
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Natural infections expose the immune system to escalating antigen and inflammation over
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
Beyond antigens and adjuvants: formulating future vaccines
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has
motivated studies of the formulation of vaccines to control how, when, and where antigens …
motivated studies of the formulation of vaccines to control how, when, and where antigens …
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
MF Bachmann, GT Jennings - Nature Reviews Immunology, 2010 - nature.com
Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …
Peyer's patches: organizing B‐cell responses at the intestinal frontier
A Reboldi, JG Cyster - Immunological reviews, 2016 - Wiley Online Library
Secondary lymphoid tissues share the important function of bringing together antigens and
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …
Engineering synthetic vaccines using cues from natural immunity
Vaccines aim to protect against or treat diseases through manipulation of the immune
response, promoting either immunity or tolerance. In the former case, vaccines generate …
response, promoting either immunity or tolerance. In the former case, vaccines generate …