Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Quantitative assays for human DNA and mRNA were used to examine the paradox that
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …

Background Histopathology has initially been and is still used to diagnose infectious,
degenerative or neoplastic diseases in humans or animals. In addition to qualitative …

Astrocytes are the major glial cell of the central nervous system (CNS), providing both
metabolic and physical support to other neural cells. After injury, astrocytes become reactive …

Multiple sclerosis (MS) is a relatively common and etiologically unknown disease with no
cure treatment. It is the leading cause of neurological disability in young adults, affecting …

Mesenchymal stem cells (MSCs) possess a set of several fairly unique properties which
make them ideally suited both for cellular therapies/regenerative medicine, and as vehicles …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …

Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine
family that signal through intracellular chains of the gp130/LIFRβ receptor. The severe …

Mesenchymal stem cell (MSC)-based therapeutics are showing significant benefit in multiple
clinical trials conducted by both academic and commercial organizations, but obstacles …