Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

INTRODUCTION The period from peri-implantation to gastrulation is critical for mammalian
embryogenesis. During this time, connections between embryonic and maternal tissues are …

An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …

In humans, germline competency and the specification of primordial germ cells (PGCs) are
thought to occur in a restricted developmental window during early embryogenesis. Despite …

Human primordial germ cells (hPGCs) are the first embryonic progenitors in the germ cell
lineage, yet the molecular mechanisms required for hPGC formation are not well …

A major challenge in stem cell differentiation is the availability of bioassays to prove cell
types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of …

Cellular replacement therapies for neurological conditions use human embryonic stem cell
(hESC)-or induced pluripotent stem cell (hiPSC)-derived neurons to replace damaged or …

Due to their ability to standardize key physiological parameters, stirred suspension
bioreactors can potentially scale the production of quality-controlled pluripotent stem cells …

Abstract Specification of germ cell-like cells from induced pluripotent stem cells has become
a clinically relevant tool for research. Research on initial embryonic processes is often …