Astrocytic K+ clearance during disease progression in amyotrophic lateral sclerosis

R Stevenson, E Samokhina, A Mangat, I Rossetti… - Glia, 2023 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which patients lose
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …

A method for assessing tissue respiration in anatomically defined brain regions

E Underwood, JB Redell, J Zhao, AN Moore… - Scientific reports, 2020 - nature.com
The survival and function of brain cells requires uninterrupted ATP synthesis. Different brain
structures subserve distinct neurological functions, and therefore have different energy …

Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum

R Gamage, I Rossetti, G Niedermayer, G Münch… - Journal of …, 2023 - Springer
Background Low-grade, chronic inflammation in the central nervous system characterized
by glial reactivity is one of the major hallmarks for aging-related neurodegenerative …

Astrocytic modulation of cortical oscillations

A Bellot-Saez, G Cohen, A van Schaik, L Ooi… - Scientific reports, 2018 - nature.com
Brain waves are rhythmic voltage oscillations emerging from the synchronization of
individual neurons into a neuronal network. These oscillations range from slow to fast …

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

Y Buskila, O Kékesi, A Bellot-Saez, W Seah… - Cell death & …, 2019 - nature.com
Amyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND) in which
humans lose motor functions due to progressive loss of motoneurons in the cortex …

The differential impact of acute microglia activation on the excitability of cholinergic neurons in the mouse medial septum

O Kékesi, H Liang, G Münch, JW Morley… - Brain Structure and …, 2019 - Springer
The medial septal nucleus is one of the basal forebrain nuclei that projects cholinergic input
to the hippocampus and cortex. Two of the hallmarks of Alzheimer's disease (AD) are a …

Starting a Synthetic Biological Intelligence Lab from Scratch

MS Tanveer, D Patel, HE Schweiger… - arXiv preprint arXiv …, 2024 - arxiv.org
With the recent advancements in artificial intelligence, researchers and industries are
deploying gigantic models trained on billions of samples. While training these models …

Extending the life span of acute neuronal tissue for imaging and electrophysiological studies

Y Buskila, A Bellot-Saez, O Kékesi, M Cameron… - Basic neurobiology …, 2020 - Springer
Slice preparations of neuronal tissue are among the most commonly used experimental
approaches in the field of neuroscience. They are employed for a variety of techniques …

Analyzing the size, shape, and directionality of networks of coupled astrocytes

S Condamine, D Verdier… - Journal of Visualized …, 2018 - pmc.ncbi.nlm.nih.gov
It has become increasingly clear that astrocytes modulate neuronal function not only at the
synaptic and single-cell levels, but also at the network level. Astrocytes are strongly …

Potassium homeostasis during disease progression of Alzheimers Disease

E Samokhina, AK Mangat, CS Malladi, E Gyengesi… - bioRxiv, 2024 - biorxiv.org
Alzheimers disease (AD) is an age-dependent neurodegenerative disorder characterized by
neuronal loss leading to dementia and ultimately death. Whilst the loss of neurons is central …