Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in
inflammation and host defense; however, the underlying molecular mechanism remains …

BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal
melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex …

Osteoporosis is a major public health problem. Currently, there are no orally available
therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates …

The renal actions of parathyroid hormone (PTH) promote 1, 25-vitamin D generation;
however, the signaling mechanisms that control PTH-dependent vitamin D activation remain …

Abstract Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive
roles in cancer. There is clinical success of targeting this complex in PRC2-dependent …

Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …