Sleep is often viewed as a vulnerable state that is incompatible with behaviours that nourish
and propagate species. This has led to the hypothesis that sleep has survived because it …

The laboratory mouse has become the predominant test species in biomedical research.
The number of papers that translate or extrapolate data from mouse to human has grown …

Endothermic organisms rely on tightly balanced energy budgets to maintain a regulated
body temperature and body mass. Metabolic phenotyping of mice, therefore, often includes …

Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …

Homeostatic temperature regulation is fundamental to mammalian physiology and is
controlled by acute and chronic responses of local, endocrine and nervous regulators. Here …

Advances in biologging techniques over the past 20 years have allowed for the remote and
continuous measurement of body temperatures in free‐living mammals. While there is an …

Leptin-deficient (Lepob/ob) mice are obese, diabetic, and infertile. Ablation of neurons that
make agouti-related protein (AgRP) in moderately obese adult Lepob/ob mice caused …

All organisms face tradeoffs with regard to how limited energy resources should be invested.
When is it most favorable to grow, to reproduce, how much lipid should be allocated to …

Considerable variation is inherent both within and between comparative physiological data
sets. Known sources for such variation include diet, gender, time of day and season of …

Feeding and sleep are behaviours fundamental to survival, and as such are subject to
powerful homeostatic control. Of course, these are mutually exclusive behaviours, and …