Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …

Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer
disease, which is primarily described as a microtubule-associated protein, has also been …

To commemorate the 50th anniversary of the Society of Toxicology, this special edition
article reviews the history and current scope of xenobiotic metabolism and transport, with …

Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal
cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the …

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important
nuclear receptors involved in the regulation of cellular responses from exposure to many …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins
involved in xenobiotic metabolism. This is achieved largely via activation of cellular …

Phenobarbital is a central nervous system depressant that also indirectly activates nuclear
receptor constitutive active androstane receptor (CAR), which promotes drug and energy …

Glutathione transferase (GST) isoezymes are encoded by three separate families of genes
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …