Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Highlights•The biofilm formation process and its microenvironmental characteristics are
described.•Biofilm microenvironment-responsive nanoparticles for anti-infection are …

In recent years, much progress has been motivated in stimuli-responsive nanocarriers,
which could response to the intrinsic physicochemical and pathological factors in diseased …

Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Until now, enormous smart materials have been engineered with endogenous stimulators
such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous …

Hypoxia is a salient feature observed in most solid malignancies that holds a pivotal role in
angiogenesis, metastasis and resistance to conventional cancer therapeutic approaches …

The exploitation of specific guests which can respond to external stimuli is the main
approach for the construction of stimuli‐responsive supramolecular polymers (SPs) based …

Hypoxia causes the expression of signaling molecules which regulate cell division, lead to
angiogenesis, and further, in the tumor microenvironment, promote resistance to …

Background Cancer is one of the deadliest threats to human health. Abnormal
physiochemical conditions and dysregulated biosynthetic intermediates in the tumor …

Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low
side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for …