Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
The post-GWAS era: from association to function
MD Gallagher, AS Chen-Plotkin - The American Journal of Human …, 2018 - cell.com
During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
[HTML][HTML] TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
J Baggen, M Jacquemyn, L Persoons, E Vanstreels… - Cell, 2023 - cell.com
SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
Age-dependent formation of TMEM106B amyloid filaments in human brains
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …
[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
A major role for common genetic variation in anxiety disorders
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–
60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case …
60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case …
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
PM Sullivan, X Zhou, AM Robins, DH Paushter… - Acta neuropathologica …, 2016 - Springer
Hexanucleotide repeat expansion in the C9orf72 gene is a leading cause of frontotemporal
lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS). Reduced expression of …
lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS). Reduced expression of …
Lysosomal size matters
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …
signaling and quality control functions. Lysosomes are not static and they respond …
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging
Several studies using cryogenic electron microscopy (cryo-EM) techniques recently reported
the isolation and characterization of novel protein filaments, composed of a C-terminal …
the isolation and characterization of novel protein filaments, composed of a C-terminal …
Alteration of the micro RNA network during the progression of Alzheimer's disease
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …