With the application of modern investigative technologies, cholestatic liver diseases of
genetic etiology are increasingly identified as the root cause of previously designated …

Background Progressive familial intrahepatic cholestasis (PFIC) is a group of inherited
paediatric liver diseases resulting from mutations in genes that impact bile secretion. We …

With the application of modern investigative technologies, cholestatic liver diseases of
genetic etiology are increasingly identified as the root cause of previously designated …

The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics
and structural integrity. Here, we show that plectin, a major intermediate filament-based …

Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability
through the integration of intermediate filaments (IFs) with cell junctions. Here, we …

Cholestasis is one of the most common clinical symptom of liver diseases. If patients do not
receive effective treatment, cholestasis can evolve into liver fibrosis, cirrhosis and ultimately …

Objectives To determine how advanced genetic analysis methods may help in clinical
diagnosis. Study design We report a combined genetic diagnosis approach for patients with …

Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to
intermediate filaments of all types and connects them to junctional complexes, organelles …

Plectin is a cytoskeletal linker of intermediate filaments, encoded by the PLEC gene.
Recently, plectin mutations have been identified in a pair of siblings with progressive familial …

LncRNA-ATB在胆汁淤积性肝病患者血清中的表达及意义 主页 简体中文 English 简体中文 登录
BPG Management System F6Publishing-Submit a Manuscript F6Publishing-世界华人消化杂志 …