A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii

B Luna, V Trebosc, B Lee, M Bakowski, A Ulhaq… - Nature …, 2020 - nature.com
Industry screens of large chemical libraries have traditionally relied on rich media to ensure
rapid bacterial growth in high-throughput testing. We used eukaryotic, nutrient-limited growth …

An oral fluorouracil prodrug, capecitabine, mitigates a Gram-positive systemic infection in mice

JR McLeod, PA Harvey, CS Detweiler - Microbiology spectrum, 2021 - Am Soc Microbiol
New classes of antibiotics are needed to fight bacterial infections, and repurposing existing
drugs as antibiotics may enable rapid deployment of new treatments. Screens for …

Functional Prediction of Biological Profile During Eutrophication in Marine Environment

Y Sbaoui, B Nouadi, A Ezaouine… - … and Biology Insights, 2022 - journals.sagepub.com
In the marine environment, coastal nutrient pollution and algal blooms are increasing in
many coral reefs and surface waters around the world, leading to higher concentrations of …

[图书][B] Discovery of novel antibiotics via Streptomyces sporulation

S McAuley - 2019 - search.proquest.com
Streptomyces are filamentous bacteria known for producing a wide range of bioactive
molecules. In addition to being nature's chemists they have a unique multicellular life-cycle …