Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality
rate. Although the current standard therapy consists of surgery followed by radiation and …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …

Glioma is one of the most common malignant tumors of the central nervous system and is
characterized by extensive infiltrative growth, neovascularization, and resistance to various …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical
resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after …

The repressive Hippo pathway has a profound tumour suppressive role in cancer by
restraining the growth-promoting function of the transcriptional coactivator, YAP. We …

Glioma is the most common intracranial primary malignancy, with limited treatment options
and a poor overall survival (OS). Immunotherapy has been used successfully in various …

Background: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate
the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and …