Patient-specific inverse modeling of in vivo cardiovascular mechanics with medical image-derived kinematics as input data: concepts, methods, and applications

JH Bracamonte, SK Saunders, JS Wilson, UT Truong… - Applied Sciences, 2022 - mdpi.com
Inverse modeling approaches in cardiovascular medicine are a collection of methodologies
that can provide non-invasive patient-specific estimations of tissue properties, mechanical …

An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves

S Jett, D Laurence, R Kunkel, AR Babu… - Journal of the …, 2018 - Elsevier
Valvular heart diseases are complex disorders, varying in pathophysiological mechanism
and affected valve components. Understanding the effects of these diseases on valve …

Manifold learning based data-driven modeling for soft biological tissues

Q He, DW Laurence, CH Lee, JS Chen - Journal of biomechanics, 2021 - Elsevier
Data-driven modeling directly utilizes experimental data with machine learning techniques
to predict a material's response without the necessity of using phenomenological constitutive …

Peridynamic neural operators: A data-driven nonlocal constitutive model for complex material responses

S Jafarzadeh, S Silling, N Liu, Z Zhang, Y Yu - Computer Methods in …, 2024 - Elsevier
Neural operators, which can act as implicit solution operators of hidden governing
equations, have recently become popular tools for learning the responses of complex real …

A physics-guided neural operator learning approach to model biological tissues from digital image correlation measurements

H You, Q Zhang, CJ Ross… - Journal of …, 2022 - asmedigitalcollection.asme.org
We present a data-driven workflow to biological tissue modeling, which aims to predict the
displacement field based on digital image correlation (DIC) measurements under unseen …

FEBio FINESSE: An open-source finite element simulation approach to estimate in vivo heart valve strains using shape enforcement

DW Laurence, PM Sabin, AM Sulentic… - Annals of Biomedical …, 2024 - Springer
Purpose Finite element simulations are an enticing tool to evaluate heart valve function;
however, patient-specific simulations derived from 3D echocardiography are hampered by …

On valve interstitial cell signaling: the link between multiscale mechanics and mechanobiology

DP Howsmon, MS Sacks - Cardiovascular engineering and technology, 2021 - Springer
Heart valves function in one of the most mechanically demanding environments in the body
to ensure unidirectional blood flow. The resident valve interstitial cells respond to this …

A noninvasive method for the determination of in vivo mitral valve leaflet strains

BV Rego, AH Khalighi, A Drach, EK Lai… - … journal for numerical …, 2018 - Wiley Online Library
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …

An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets

KE Kramer, CJ Ross, DW Laurence, AR Babu, Y Wu… - Acta Biomaterialia, 2019 - Elsevier
Atrioventricular heart valves (AHVs) are composed of structurally complex and
morphologically heterogeneous leaflets. The coaptation of these leaflets during the cardiac …

Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains

H Narang, BV Rego, AH Khalighi, A Aly… - Annals of biomedical …, 2021 - Springer
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …