Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …

The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental
cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways …

Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for
a considerable number of human and animal diseases. Alphavirus members include …

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries
for completion of their replication cycle. The recent discovery of the heterogeneous …

Abstract Structure–function studies have defined two classes of viral membrane-fusion
proteins that have radically different architectures but adopt a similar overall'hairpin' …

Many enveloped viruses invade cells via endocytosis and use different environmental
factors as triggers for virus-endosome fusion that delivers viral genome into cytosol …

In biomembrane fusion pathways, membranes are destabilized through insertions of
amphipathic protein segments, lipid reorganization via hemifusion, protein restructuring, and …

Conclusions The results reviewed suggest that membrane fusion in diverse biological fusion
reactions involves formation of some specific intermediates: stalks and pores. Energy of …

Publisher Summary In addition to its many other functions, the plasma membrane of
eukaryotic cells serves as a barrier against invading parasites and viruses. It is not …