Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women …

Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

The state of somatic energy stores in metazoans is communicated to the brain, which
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …

Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which …

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Under normal conditions, food intake and energy expenditure are balanced by a
homeostatic system that maintains stability of body fat content over time. However, this …