Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

The radiation-induced bystander effect represents a paradigm shift in our understanding of
the radiobiological effects of ionizing radiation, in that extranuclear and extracellular events …

The central dogma of radiation biology, that biological effects of ionizing radiation are a
direct consequence of DNA damage occurring in irradiated cells, has been challenged by …

The term radiation-induced bystander effect is used to describe radiation-induced biological
changes that manifest in unirradiated cells remaining within an irradiated cell population …

Purposes: To review research progress on the molecular mechanisms of low dose ionizing
radiation (LDIR)-induced hormesis, adaptive responses, radioresistance, bystander effects …

For many years, targeted DNA damage caused by radiation has been considered the main
cause of various biological effects. Based on this paradigm, any small amount of radiation is …

The “radiation-induced bystander effect,” in which irradiated cells can induce genomic
instability in unirradiated neighboring cells, has important implications for cancer …

Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton
beams are used to precisely deliver the dose to the tumor target but is generally considered …

Exposure of cells to any form of ionizing radiation (IR) is expected to induce a variety of DNA
lesions, including double strand breaks (DSBs), single strand breaks (SSBs) and oxidized …