Nuclear sequence data, often from multiple loci, are increasingly being employed in
analyses of population structure and history, yet there has been relatively little evaluation of …

Background A widely-used approach for screening nuclear DNA markers is to obtain
sequence data and use bioinformatic algorithms to estimate which two alleles are present in …

Background For prevention of joint destruction in rheumatoid arthritis, optimal management
of therapy with disease-modifying antirheumatic drugs is essential. Pharmacogenomic …

Abstract Background: Arylamine N-acetyltransferase 2 (CoASAc; NAT2, EC 2.3. 1.5) is a
drug-metabolizing enzyme that displays common polymorphisms leading to impaired drug …

Hepatotoxicity is frequently reported as an adverse reaction during the treatment of
tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to …

Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and
bladder cancer has been consistently observed in epidemiologic studies. However …

Purpose: Genetic polymorphisms in the N-acetyltransferase 2 gene determine the individual
acetylator status, which influences both the toxicity and efficacy profile of acetylated drugs …

We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2)
haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single …

The role of N-acetyltransferase 2 (NAT2) polymorphism in breast cancer is still unclear. We
explored the associations between potential sources of exposure to aromatic and …

Background: Arylamine N-acetyltransferase 2 (NAT2) polymorphism was previously
reported to have association with the risk of drug toxicities and the development of various …