For a long time, cysteine cathepsins were considered primarily as proteases crucial for
nonspecific bulk proteolysis in the endolysosomal system. However, this view has …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

The niche concept was originally developed to describe the location of normal neural stem
cells (NSCs) in the subependymal layer of the sub-ventricular zone. In this paper, its …

Previous researches have demonstrated the meaning of CTSB for the progress of several
tumors, whereas few clues about its immunological characteristic in gliomas. Here we …

Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process
that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in …

Introduction In view of other candidate proteins from the cathepsin family of proteases
holding great potential in being targeted during cancer therapy, the importance of Cathepsin …

Immunohistochemistry (IHC) specifically localizes proteins in cells and tissues, but
methodologies vary widely. Therefore, we performed a methodological IHC optimization and …

In keeping with recent developments in basic research; the importance of the Cathepsins as
targets in cancer therapy have taken on increasing importance and given rise to a number of …

Glioblastoma is the most aggressive primary brain tumor. Slowly dividing and therapy-
resistant glioblastoma stem cells (GSCs) reside in protective peri-arteriolar niches and are …

Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the
endolysosomal compartment where they mediate protein degradation and turnover …