Several 'classical'protein tyrosine phosphatases are attractive therapeutic targets, including
PTP1B for obesity and Type II diabetes; SHP2 for cancer and Lyp for rheumatoid arthritis …

Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell
physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine …

Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of
Alzheimer's Disease | PLOS Biology Skip to main content Advertisement PLOS Biology Browse …

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107
genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate …

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative
regulators of signaling mediated through the T-cell antigen receptor (TCR) and are thought …

Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways
by controlling the level of tyrosine phosphorylation. The past decade has seen a vast …

Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-
117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 μM …

Background—A limitation of current antiplatelet therapies is their inability to separate
thrombotic events from bleeding occurrences. A better understanding of the molecular …

Therapeutic inhibition of protein tyrosine phosphatase activity is a compelling yet
challenging approach to the treatment of human disease. Toward this end, a library of 40 …