From sequence to consequence: Deciphering the complex cis-regulatory landscape
Cell type-specific expression of genes plays a pivotal role in the development and evolution
of multicellular organisms over millions of years. The majority of regulatory control resides …
of multicellular organisms over millions of years. The majority of regulatory control resides …
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Transcriptional noise, or heterogeneity, is important in cellular development and in disease.
The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we use …
The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we use …
Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements
H Abewe, A Richey, JM Vahrenkamp… - bioRxiv, 2024 - biorxiv.org
Transcriptional enhancers can regulate individual or multiple genes through long-range
three-dimensional (3D) genome interactions, and these interactions are commonly altered in …
three-dimensional (3D) genome interactions, and these interactions are commonly altered in …