Dysregulated T-cell homeostasis and decreased CD30+ Treg proliferating in aplastic anemia

N Sun, M Zhang, J Kong, J Li, Y Dong, X Wang, L Fu… - Heliyon, 2024 - cell.com
Aplastic anemia (AA) is an autoimmune hematopoietic disease mediated by autoreactive T
cells leading to bone marrow failure. However, the precise role of autoreactive T cells in the …

Early bone marrow alterations in patients with adenosine deaminase 2 deficiency across disease phenotypes and severities

D Bulté, F Barzaghi, C Mesa-Nuñez… - Journal of Allergy and …, 2024 - Elsevier
Background Deficiency of adenosine deaminase 2 (DADA2) is a complex monogenic
disease caused by recessive mutations in the ADA2 gene. DADA2 exhibits a broad clinical …

Integrating network pharmacology and experimental validation to explore the mitophagy‐associated pharmacological mechanism of modified Shisiwei Jianzhong …

Y Zhang, J Wang, B Wang, Y Gao, S Lin… - Biomedical …, 2024 - Wiley Online Library
The aim of this work was to investigate the therapeutic effect of modified Shisiwei Jianzhong
Decoction (SJD) on aplastic anemia (AA) and its potential pharmacological mechanism from …