Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced changes
in chemical shift, CIS) follows changes in the chemical shifts of a protein when a ligand is …

Protein–ligand interactions have been commonly studied through static structures of the
protein–ligand complex. Recently, however, there has been increasing interest in …

The drug discovery landscape has undergone a significant transformation over the past
decade, owing to research endeavors in a wide range of areas leading to strategies for …

One of the intrinsic properties of proteins is their capacity to interact selectively with other
molecules in their environment, inducing many chemical equilibria each differentiated by the …

The p53 pathway is inactivated in almost all types of cancer by mutations in the p53
encoding gene or overexpression of the p53 negative regulators, Mdm2 and/or Mdmx …

Recognition and repair of double-stranded DNA breaks (DSB) involves the targeted
recruitment of BRCA tumor suppressors to damage foci through binding of both ubiquitin …

T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR.
ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem SH2 (tSH2) …

Evidence is presented that binding isotherms, simple or biphasic, can be extracted directly
from noninterpreted, complex 2D NMR spectra using principal component analysis (PCA) to …

All retroviruses encode the enzyme, reverse transcriptase (RT), which is involved in the
conversion of the single-stranded viral RNA genome into double-stranded DNA. RT is a …

Protein turnover in cells is regulated by the ATP dependent activity of the Hsp90 chaperone.
In concert with accessory proteins, ATP hydrolysis drives the obligate Hsp90 dimer through …