The formation of insulin amyloid can dramatically impact glycemic control in patients with
diabetes, making it an important therapeutic consideration. In addition, the cost associated …

Active accumulation of the data on new amyloids continuing nowadays dissolves
boundaries of the term “amyloid”. Currently, it is most often used to designate aggregates …

Amyloid formation is a hallmark of many medical diseases including diabetes type 2,
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …

Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …

Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …

Abrupt aggregation of misfolded proteins is a hallmark of a large number of severe
pathologies, including diabetes types 1 and 2, Alzheimer, and Parkinson diseases. A …

Phosphatidic acid (PA) is a unique plasma membrane lipid that contains fatty acids (FAs)
with different lengths and degrees of unsaturation. Under physiological conditions, PA acts …

Fluorescent probes thioflavin T (ThT) and 1-anilino-8-naphthalene sulfonate (ANS) are
widely used to study amyloid fibrils that accumulate in the body of patients with serious …

Deposits of protein misfolding and/or aggregates are a pathological hallmark of amyloid-
related diseases. For instance, insulin amyloid fibril deposits have been observed in patients …

Human insulin is a widely used model protein for the study of amyloid formation as both
associated to insulin injection amyloidosis in type II diabetes and highly prone to form …