Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional
plasticity in neural circuits of pain have provided mechanistic insights and linked various …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Pain and stress share significant conceptual and physiological overlaps. Both phenomena
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …

Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain
represents a complex disorder with anxio-depressive symptoms and cognitive deficits …

Conservative, surgical and pharmacological strategies for chronic low back pain (CLBP)
management offer at best modest effect sizes in reducing pain and related disability …

Introduction: The mechanism of sensitization of the central nervous system partly explains
the chronic pain experience in many patients, but the etiological mechanisms of this central …

Human neuroimaging studies and complementary animal experiments now identify the
gross elements of the brain involved in the chronification of pain. We briefly review these …

Objectives Knee osteoarthritis (KOA) is a common degenerative joint disease with no
satisfactory intervention. Recently, both physical and mindfulness exercises have received …

Microglia are important mediators of neuroinflammation, which underlies neuropathic pain.
However, the molecular checkpoints controlling microglial reactivity are not well-understood …