Engineering stem cell-derived extracellular matrices: decellularization, characterization, and biological function
Stem cells, including mesenchymal stem cells and pluripotent stem cells, have attracted
considerable attention in tissue engineering and regenerative medicine primarily because of …
considerable attention in tissue engineering and regenerative medicine primarily because of …
PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
LJ Celada, JA Kropski, JD Herazo-Maya… - Science translational …, 2018 - science.org
Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …
therapeutic options. Previous genetic and immunologic investigations suggest common …
Vascular derived ECM improves therapeutic index of BMP‐2 and drives vascularized bone regeneration
J Chen, X Zhou, W Sun, Z Zhang, W Teng, F Wang… - Small, 2022 - Wiley Online Library
Vascularized osteogenesis is essential for successful bone regeneration, yet its realization
during large size bone defect healing remains challenging due to the difficulty to couple …
during large size bone defect healing remains challenging due to the difficulty to couple …
Bioreactor culture duration of engineered constructs influences bone formation by mesenchymal stem cells
D Mitra, J Whitehead, OW Yasui, JK Leach - Biomaterials, 2017 - Elsevier
Perfusion culture of mesenchymal stem cells (MSCs) seeded in biomaterial scaffolds
provides nutrients for cell survival, enhances extracellular matrix deposition, and increases …
provides nutrients for cell survival, enhances extracellular matrix deposition, and increases …
Extracellular matrix-coated composite scaffolds promote mesenchymal stem cell persistence and osteogenesis
JN Harvestine, NL Vollmer, SS Ho, CA Zikry… - …, 2016 - ACS Publications
Composite scaffolds of bioactive glass and poly (lactide-co-glycolide) provide advantages
over homogeneous scaffolds, yet their therapeutic potential can be improved by strategies …
over homogeneous scaffolds, yet their therapeutic potential can be improved by strategies …
FLIm-guided Raman imaging to study cross-linking and calcification of bovine pericardium
TA Shaik, A Alfonso-García, X Zhou, KM Arnold… - Analytical …, 2020 - ACS Publications
Bovine pericardium (BP) is a vascular biomaterial used in cardiovascular surgery that is
typically cross-linked for masking antigenicity and enhance stability. There is a need for …
typically cross-linked for masking antigenicity and enhance stability. There is a need for …
Cell-secreted extracellular matrix, independent of cell source, promotes the osteogenic differentiation of human stromal vascular fraction
JN Harvestine, H Orbay, JY Chen, DE Sahar… - Journal of Materials …, 2018 - pubs.rsc.org
Lipoaspirates contain a readily accessible heterogeneous cell source for use in bone
regeneration collectively referred to as the stromal vascular fraction (SVF). However, the …
regeneration collectively referred to as the stromal vascular fraction (SVF). However, the …
Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging
BE Sherlock, JN Harvestine, D Mitra… - … of biomedical optics, 2018 - spiedigitallibrary.org
We investigate the use of a fiber-based, multispectral fluorescence lifetime imaging (FLIm)
system to nondestructively monitor changes in mechanical properties of collagen hydrogels …
system to nondestructively monitor changes in mechanical properties of collagen hydrogels …
[HTML][HTML] Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices
SW Fok, RCH Gresham, W Ryan, B Osipov… - … in Bioengineering and …, 2023 - frontiersin.org
Recombinant growth factors are used in tissue engineering to stimulate cell proliferation,
migration, and differentiation. Conventional methods of growth factor delivery for therapeutic …
migration, and differentiation. Conventional methods of growth factor delivery for therapeutic …
Exogenous lysyl oxidase‐like 2 and perfusion culture induce collagen crosslink formation in osteogenic grafts
D Mitra, OW Yasui, JN Harvestine, JM Link… - Biotechnology …, 2019 - Wiley Online Library
Lysyl oxidase (LOX)‐mediated collagen crosslinking can regulate osteoblastic phenotype
and enhance mechanical properties of tissues, both areas of interest in bone tissue …
and enhance mechanical properties of tissues, both areas of interest in bone tissue …