Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …

Multipass membrane proteins play numerous roles in biology and include receptors,
transporters, ion channels and enzymes,. How multipass proteins are co-translationally …

Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait
provides influenza with the advantage of access to the nuclear machinery during replication …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Most membrane proteins are synthesized on endoplasmic reticulum (ER)-bound ribosomes
docked at the translocon, a heterogeneous ensemble of transmembrane factors operating …

The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Misfolded proteins of the endoplasmic reticulum (ER) are discarded by a conserved process,
called ER-associated protein degradation (ERAD). ERAD substrates are retro-translocated …

Peroxisomes are ubiquitous organelles that house various metabolic reactions and are
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …