Imagining the future of optical microscopy: everything, everywhere, all at once

H Balasubramanian, CM Hobson, TL Chew… - Communications …, 2023 - nature.com
The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

A survey of physical methods for studying nuclear mechanics and mechanobiology

CM Hobson, MR Falvo, R Superfine - APL bioengineering, 2021 - pubs.aip.org
It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …

The future of bioimage analysis: a dialog between mind and machine

LA Royer - Nature Methods, 2023 - nature.com
The field of bioimage analysis is poised for a major transformation, owing to advancements
in imaging technologies and artificial intelligence. The emergence of multimodal foundation …

When light meets biology–how the specimen affects quantitative microscopy

MA Reiche, JS Aaron, U Boehm… - Journal of Cell …, 2022 - journals.biologists.com
Fluorescence microscopy images should not be treated as perfect representations of
biology. Many factors within the biospecimen itself can drastically affect quantitative …

Fractional photodamage triggered by chaotic attractors in human lung epithelial cancer cells

H Martines-Arano, S Palacios-Barreto… - International Journal of …, 2022 - Elsevier
Modification in thermal transfer mechanisms induced by light in human lung epithelial
cancer cells was experimentally controlled by chaotic attractors dependent on optical …

The characterization of cell traction force on nonflat surfaces with different curvature by elastic hydrogel microspheres

Y Dong, C Wang, X Ding, X Ma… - Biotechnology and …, 2024 - Wiley Online Library
It is of great importance to study the detachment/attachment behaviors of cells (cancer cell,
immune cell, and epithelial cell), as they are closely related with tumor metastasis …

Microsphere sensors for characterizing stress fields within three-dimensional extracellular matrix

X Ding, M Li, B Cheng, Z Wei, Y Dong, F Xu - Acta Biomaterialia, 2022 - Elsevier
Stress in the three-dimensional extracellular matrix is one of the key cues in regulating
multiscale biological processes. Thus far, noticeable progress in methods and techniques …