Pancreatic ductal adenocarcinoma: current and evolving therapies

A Adamska, A Domenichini, M Falasca - International journal of molecular …, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis

QP Janssen, S Buettner, M Suker… - JNCI: Journal of the …, 2019 - academic.oup.com
Background FOLFIRINOX is a standard treatment for metastatic pancreatic cancer patients.
The effectiveness of neoadjuvant FOLFIRINOX in patients with borderline resectable …

Locally advanced pancreatic cancer: neoadjuvant therapy with folfirinox results in resectability in 60% of the patients

T Hackert, M Sachsenmaier, U Hinz… - Annals of …, 2016 - journals.lww.com
Objective: For patients with locally advanced and unresectable pancreatic cancer (PDAC),
neodadjuvant treatment and consecutive surgical exploration have been studied during the …

Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer

CR Ferrone, G Marchegiani, TS Hong, DP Ryan… - Annals of …, 2015 - journals.lww.com
Purpose: On the basis of the ACCORD trial, FOLFIRINOX is effective in metastatic pancreatic
adenocarcinoma (PDAC), making it a rational choice for locally advanced PDAC (LA). Aims …

Neoadjuvant treatment in pancreatic cancer

A Oba, F Ho, QR Bao, MH Al-Musawi… - Frontiers in …, 2020 - frontiersin.org
Thanks to the development of modern chemotherapeutic regimens, survival after surgery for
pancreatic ductal adenocarcinoma (PDAC) has improved and pancreatologists worldwide …

Preoperative modified FOLFIRINOX treatment followed by capecitabine-based chemoradiation for borderline resectable pancreatic cancer: alliance for clinical trials in …

MHG Katz, Q Shi, SA Ahmad, JM Herman… - JAMA …, 2016 - jamanetwork.com
Importance Although consensus statements support the preoperative treatment of borderline
resectable pancreatic cancer, no prospective, quality-controlled, multicenter studies of this …

Pancreatic adenocarcinoma, version 2.2014

MA Tempero, MP Malafa, SW Behrman… - Journal of the National …, 2014 - jnccn.org
The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and
management of adenocarcinomas of the exocrine pancreas and are intended to assist with …

Sarcopenia is an independent predictor of complications following pancreatectomy for adenocarcinoma

S Joglekar, A Asghar, SL Mott… - Journal of surgical …, 2015 - Wiley Online Library
Background and Objectives Sarcopenia, which is subclinical loss of skeletal muscle mass, is
commonly observed in patients with malignancy. The objective of this study is to determine …

Neoadjuvant treatment of pancreatic adenocarcinoma: a systematic review and meta-analysis of 5520 patients

M Dhir, GK Malhotra, DPS Sohal, NA Hein… - World journal of surgical …, 2017 - Springer
Background Recent years have seen standardization of the anatomic definitions of
pancreatic adenocarcinoma, and increasing utilization of neoadjuvant therapy (NAT). The …

FOLFIRINOX-based neoadjuvant therapy in borderline resectable or unresectable pancreatic cancer: a meta-analytical review of published studies

F Petrelli, A Coinu, K Borgonovo, M Cabiddu… - Pancreas, 2015 - journals.lww.com
Objective The use of neoadjuvant chemotherapy can enable surgical resection of borderline
resectable or unresectable pancreatic cancer (PC). The aim of this study was to evaluate the …