Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

Histone H1 is the most variable histone and its role at the epigenetic level is less
characterized than that of core histones. In vertebrates, H1 is a multigene family, which can …

Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

Chronic liver disease (CLD) represents a global health problem, accounting for the heavy
burden of disability and increased health care utilization. Epigenome alterations play an …

The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers.
Human brain development is tightly regulated and sensitive to cellular alterations caused by …

During mammalian reproduction, germ cell chromatin packaging is key to prepare parental
genomes for fertilization and to initiate embryonic development. While chromatin …

Abstract Histone Gene Cluster 1 Member E, HIST1H1E, encodes Histone H1. 4, is one of a
family of epigenetic regulator genes, acts as a linker histone protein, and is responsible for …

H1 linker histones are a class of DNA-binding proteins involved in the formation of supra-
nucleosomal chromatin higher order structures. Eleven non-allelic subtypes of H1 are …

Chromatin dynamics can regulate all DNA-dependent processes. Access to DNA within
chromatin is orchestrated mainly by histones and their posttranslational modifications …

Abstract Human histone H1. 5, in mice called H1b, belongs to the family of linker histones
(H1), which are key players in chromatin organization. These proteins sit on top of …