From big data analysis to personalized medicine for all: challenges and opportunities

A Alyass, M Turcotte, D Meyre - BMC medical genomics, 2015 - Springer
Recent advances in high-throughput technologies have led to the emergence of systems
biology as a holistic science to achieve more precise modeling of complex diseases. Many …

The 'prime-ome': towards a holistic approach to priming

A Balmer, V Pastor, J Gamir, V Flors… - Trends in plant …, 2015 - cell.com
Plants can be primed to respond faster and more strongly to stress and multiple pathways,
specific for the encountered challenge, are involved in priming. This adaptability of priming …

Knowledge discovery and interactive data mining in bioinformatics-state-of-the-art, future challenges and research directions

A Holzinger, M Dehmer, I Jurisica - BMC bioinformatics, 2014 - Springer
Background The life sciences, biomedicine and health care are increasingly turning into a
data intensive science [2–4]. Particularly in bioinformatics and computational biology we …

Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations

A Tebani, C Afonso, S Marret, S Bekri - International journal of molecular …, 2016 - mdpi.com
The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

From smart health to smart hospitals

A Holzinger, C Röcker, M Ziefle - Smart Health: Open Problems and Future …, 2015 - Springer
Prolonged life expectancy along with the increasing complexity of medicine and health
services raises health costs worldwide dramatically. Advancements in ubiquitous computing …

A systems approach to clinical oncology uses deep phenotyping to deliver personalized care

JT Yurkovich, Q Tian, ND Price, L Hood - Nature Reviews Clinical …, 2020 - nature.com
Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

[HTML][HTML] Reproducibility2020: progress and priorities

LP Freedman, G Venugopalan, R Wisman - F1000Research, 2017 - ncbi.nlm.nih.gov
The preclinical research process is a cycle of idea generation, experimentation, and
reporting of results. The biomedical research community relies on the reproducibility of …

Implementing the FAIR Data Principles in precision oncology: review of supporting initiatives

C Vesteghem, RF Brøndum, M Sønderkær… - Briefings in …, 2020 - academic.oup.com
Compelling research has recently shown that cancer is so heterogeneous that single
research centres cannot produce enough data to fit prognostic and predictive models of …

Information practices for sustainability: Role of iSchools in achieving the UN sustainable development goals (SDGs)

G Chowdhury, K Koya - Journal of the Association for …, 2017 - Wiley Online Library
In September 2015, the United Nations (UN) General Assembly passed a resolution
identifying 17 Sustainable Development Goals (SDGs) and 169 associated targets, and …

[PDF][PDF] Big data and environmental sustainability: a conversation starter

A Keeso - Smith School of Enterprise and the Environment …, 2014 - academia.edu
Big data, referring broadly to,“the ability of society to harness information in novel ways to
produce useful insights or goods and services of significant value”(Mayer-Schönberger and …