One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells
can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the …

Biologists have long recognized that dramatic bending of a cell sheet may be driven by even
modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like …

The organization of cells, emerging from cell–cell interactions, can give rise to collective
properties. These properties are adaptive when together cells can face environmental …

Mechanical stresses are ever present in the cellular environment, whether through external
forces that are applied to tissues or endogenous forces that are generated within the active …

We investigated the forces that connect the genetic program of development to
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for …

Although it is rarely considered so in modern developmental biology, morphogenesis is
fundamentally a biomechanical process, and this is especially true of one of the first major …

Force production and the propagation of stress and strain within embryos and organisms are
crucial physical processes that direct morphogenesis. In addition, there is mounting …

Soft biological tissues often undergo large (nearly) elastic deformations that can be
analyzed using the nonlinear theory of elasticity. Because of the varied approaches to …

Historically the culture of mammalian cells in the laboratory has been performed on planar
substrates with media cocktails that are optimized to maintain phenotype. However, it is …

As the gateway to shaping the body plan, gastrulation is an important problem in
developmental biology, and recent advances in cell biology have overcome some of the …