Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Lipolysis: cellular mechanisms for lipid mobilization from fat stores

GF Grabner, H Xie, M Schweiger, R Zechner - Nature metabolism, 2021 - nature.com
The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

R Patel, A Santoro, P Hofer, D Tan, M Oberer… - Nature, 2022 - nature.com
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Adipose tissue remodeling in pathophysiology

C Auger, S Kajimura - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death

M Danielli, L Perne, E Jarc Jovičić… - Frontiers in Cell and …, 2023 - frontiersin.org
Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic
kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic …

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health

M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway

X Zheng, W Huang, Q Li, Y Chen, L Wu… - Microbiology …, 2023 - Am Soc Microbiol
Obesity, defined as a disorder of lipid metabolism caused by white fat accumulation, is
closely related to the gut microbiota. Akkermansia muciniphila (Akk), one of the most …

Fatty acid esters of hydroxy fatty acids (FAHFAs) are associated with diet, BMI, and age

T Kellerer, K Kleigrewe, B Brandl, T Hofmann… - Frontiers in …, 2021 - frontiersin.org
Background: Fatty acid esters of hydroxy fatty acids (FAHFAs) are a group of fatty acids with
potential anti-inflammatory and anti-diabetic effects. The blood levels of FAHFAs and their …

Exploring foods as natural sources of FAHFAs—A review of occurrence, extraction, analytical techniques and emerging bioactive potential

TM Olajide, W Cao - Trends in Food Science & Technology, 2022 - Elsevier
Background Fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of recently
discovered novel lipids gaining increasing attention due to their diverse biological roles …