Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …

Dilated cardiomyopathy (DCM) is a common condition, which carries significant mortality
from sudden cardiac death and pump failure. Left ventricular ejection fraction has …

Cardiac arrhythmias are common, often the first, and sometimes the life-threatening
manifestations of hereditary cardiomyopathies. Pathogenic variants in several genes known …

Background: Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical
phenotypes are common in genetic DCM, but their exact contribution to the clinical course …

Background: Sudden cardiac arrest (SCA) and sudden unexplained death (SUD) are feared
sequelae of many genetic heart diseases. In rare circumstances, pathogenic variants in …

Introduction: Familial dilated cardiomyopathy (DCM) is clinically variable and has been
associated with mutations in more than 50 genes. Rapid improvements in DNA sequencing …

Aims To examine the relevance of genetic and cardiovascular magnetic resonance (CMR)
features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD) …

Background Truncating variants in titin (TTNtv) are the most common cause of dilated
cardiomyopathy (DCM). We evaluated the genotype-phenotype correlation in TTNtv-DCM …

Titin-truncating variants (TTNtv) are the single largest genetic cause of dilated
cardiomyopathy (DCM). In this study we modeled disease phenotypes of A-band TTNtv …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and life-threatening
ventricular arrhythmias (LTVA). Work-up and risk stratification of DCM is clinically …