Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in
many human disorders, particularly cancer, in which CNV promotes both tumorigenesis and …

Eukaryotic organisms are composed of different cell types with defined shapes and
functions. Specific cell types are produced by the process of cell differentiation, which is …

Mitogen-activated protein kinase (MAPK) pathways regulate multiple cellular behaviors,
including the response to stress and cell differentiation, and are highly conserved across …

Identifying nutrients available in the environment and utilizing them in the most efficient
manner is a challenge common to all organisms. The model filamentous fungus Neurospora …

Fusarium head blight (FHB) caused by Fusarium graminearum complex is a worldwide
devastating disease of wheat, barley, maize, and other cereals. In the field, application of …

Biofilm formation on implanted medical devices is a major source of lethal invasive infection
by Candida albicans. Filamentous growth of this fungus is tied to biofilm formation because …

Signaling mucins are evolutionarily conserved regulators of signal transduction pathways.
The signaling mucin Msb2p regulates the Cdc42p-dependent mitogen-activated protein …

Invasive fungal disease causes high morbidity and mortality among immunocompromised
patients. Resistance to conventional antifungal drugs and the toxicity associated with high …

Galactose metabolism in the yeast Saccharomyces cerevisiae is carried out by a specialized
GAL pathway consisting of structural and regulatory proteins. It is known that cells with …

Mutations in the Senataxin gene, SETX are known to cause the neurodegenerative
disorders, ataxia with oculomotor apraxia type 2 (AOA 2), and amyotrophic lateral sclerosis 4 …