An explosion of work over the last decade has produced insight into the multiple hereditary
causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 …

Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the
development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract …

Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus
and in the pathogenesis of obesity-associated disturbances of glucose and lipid …

Purpose: Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is
generally refractory to platinum-based chemotherapy. We analyze here the most …

To elucidate the molecular pathways that modulate renal cyst growth in ADPKD, we
performed global gene profiling on cysts of different size (< 1 ml, n= 5; 10–20 ml, n= 5;> 50 …

Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure,
is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the …

Polycystic kidney disease (PKD) is a genetic disorder that is characterized by cyst formation
in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle …

Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 0.5–1/100 newborns
and as a group they represent the most frequent cause for chronic kidney failure in children …

Hepatocyte nuclear factor-1β (HNF-1β) is a transcription factor required for the expression of
several renal cystic genes and whose prenatal deletion leads to polycystic kidney disease …

The autosomal recessive kidney disease nephronophthisis (NPHP) constitutes the most
frequent genetic cause of terminal renal failure in the first 3 decades of life. Ten causative …