Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

Mammalian preimplantation development, which is the period extending from fertilization to
implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one …

It has been thought that early inner cell mass (ICM) is a homogeneous population and that
cell position in the ICM leads to the formation of two lineages, epiblast (EPI) and primitive …

Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell
mass (ICM) of the E3. 5 blastocyst. Recent studies showed that EPI and PE progenitors …

Continuation of mammalian species requires the formation and development of the sexually
dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent …

To implant in the uterus, the mammalian embryo first specifies two cell lineages: the
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …

Fibroblast growth factor (FGF) signaling controls fundamental processes such as
proliferation, differentiation and migration throughout mammalian development. Here we …

It is now recognized that extensive expression heterogeneities among cells precede the
emergence of lineages in the early mammalian embryo. To establish a map of pluripotent …

Mouse pre-implantation development gives rise to the blastocyst, which is made up of at
least three distinct cell types: the trophectoderm (TE) that surrounds a cavity, and an inner …

The first lineage decision during mouse development is the establishment of trophectoderm
and inner cell mass lineages, morphologically distinguishable at the blastocyst stage. The …