The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Complex multicellular organisms require rapid and accurate transmission of information
among cells and tissues and tight coordination of distant functions. Electrical signals and …

Since it became clear that K+ shifts with exercise are extensive and can cause more than a
doubling of the extracellular [K+]([K+] s) as reviewed here, it has been suggested that these …

We have developed a mathematical model of the mouse ventricular myocyte action potential
(AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Summary N-methyl-D-aspartate (NMDA) receptors are glutamate-gated calcium-permeable
ion channels that are widely implicated in synaptic transmission and plasticity. Here, we …

Drug‐induced blockade of human ether‐a‐go‐go‐related gene (hERG) remains a major
impediment in delivering safe drugs to the market. Several drugs have been withdrawn from …

GY Oudit, Z. Kassiri, R. Sah, RJ Ramirez, C. Zobel and PH Backx. The Molecular Physiology
of the Cardiac Transient Outward Potassium Current (Ito) in Normal and Diseased …

After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …