Skeletal muscle health and function are important determinants of systemic metabolic
homeostasis and organism-wide responses, including disease outcome. While it is well …

Acute exercise and chronic exercise training elicit beneficial whole‐body changes in
physiology that ultimately depend on profound alterations to the dynamics of tissue‐specific …

How exercise elicits systemic metabolic benefits in both muscles and non-contractile tissues
is unclear. Autophagy is a stress-induced lysosomal degradation pathway that mediates …

Abstract Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes
to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin …

Human trophoblast stem cells (hTSCs) and related trophoblast organoids are state-of-the-art
culture systems that facilitate the study of trophoblast development and human placentation …

Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …

The number of studies using skeletal muscle (SkM) cell culture models to study exercise in
vitro are rapidly expanding. Progressively, more comprehensive analysis methods, such as …

Maintenance of skeletal muscle quantity and quality is essential to ensure various vital
functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and …

The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk,
especially between skeletal muscle and adipose tissue, and the role in mediating beneficial …

Extracellular vesicles (EVs) can be released from most cells in the body and act as
intercellular messengers transferring information in their cargo to affect cellular function. A …