Polysaccharide degradation by the intestinal microbiota and its influence on human health and disease

DW Cockburn, NM Koropatkin - Journal of molecular biology, 2016 - Elsevier
Carbohydrates comprise a large fraction of the typical diet, yet humans are only able to
directly process some types of starch and simple sugars. The remainder transits the large …

How glycan metabolism shapes the human gut microbiota

NM Koropatkin, EA Cameron, EC Martens - Nature Reviews …, 2012 - nature.com
Symbiotic microorganisms that reside in the human intestine are adept at foraging glycans
and polysaccharides, including those in dietary plants (starch, hemicellulose and pectin) …

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

F Cuskin, EC Lowe, MJ Temple, Y Zhu, EA Cameron… - Nature, 2015 - nature.com
Yeasts, which have been a component of the human diet for at least 7,000 years, possess
an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the …

PULDB: the expanded database of polysaccharide utilization loci

N Terrapon, V Lombard, E Drula, P Lapébie… - Nucleic acids …, 2018 - academic.oup.com
Abstract The Polysaccharide Utilization Loci (PUL) database was launched in 2015 to
present PUL predictions in∼ 70 Bacteroidetes species isolated from the human …

The Sus operon: a model system for starch uptake by the human gut Bacteroidetes

MH Foley, DW Cockburn, NM Koropatkin - Cellular and Molecular Life …, 2016 - Springer
Resident bacteria in the densely populated human intestinal tract must efficiently compete
for carbohydrate nutrition. The Bacteroidetes, a dominant bacterial phylum in the …

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

J Briliūtė, PA Urbanowicz, AS Luis, A Baslé… - Nature …, 2019 - nature.com
Glycans are the major carbon sources available to the human colonic microbiota. Numerous
N-glycosylated proteins are found in the human gut, from both dietary and host sources …

The devil lies in the details: how variations in polysaccharide fine-structure impact the physiology and evolution of gut microbes

EC Martens, AG Kelly, AS Tauzin, H Brumer - Journal of molecular biology, 2014 - Elsevier
The critical importance of gastrointestinal microbes to digestion of dietary fiber in humans
and other mammals has been appreciated for decades. Symbiotic microorganisms expand …

Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites

T Butler - European Journal of Clinical Microbiology & Infectious …, 2015 - Springer
Newly named in 1989, Capnocytophaga canimorsus is a bacterial pathogen found in the
saliva of healthy dogs and cats, and is transmitted to humans principally by dog bites. This …

Bacterial chitinases and chitin-binding proteins as virulence factors

RF Frederiksen, DK Paspaliari, T Larsen… - …, 2013 - microbiologyresearch.org
Bacterial chitinases (EC 3.2. 1.14) and chitin-binding proteins (CBPs) play a fundamental
role in the degradation of the ubiquitous biopolymer chitin, and the degradation products …

Oligosaccharides released from milk glycoproteins are selective growth substrates for infant-associated bifidobacteria

S Karav, A Le Parc… - Applied and …, 2016 - Am Soc Microbiol
Milk, in addition to nourishing the neonate, provides a range of complex glycans whose
construction ensures a specific enrichment of key members of the gut microbiota in the …