Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …

Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …

Ebola virus (EBOV) causes severe human disease. During late infection, EBOV virions are
on the skin's surface; however, the permissive skin cell types and the route of virus …