Context Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual
studies suggested they can significantly affect brain structure and account for progressive …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Context Progressive brain volume changes in schizophrenia are thought to be due
principally to the disease. However, recent animal studies indicate that antipsychotics, the …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Cortical gray matter deficits have been found in patients with schizophrenia, with evidence of
progression over time. The aim of this study was to determine the extent of progressive …

Brain development in the first 2 years after birth is extremely dynamic and likely plays an
important role in neurodevelopmental disorders, including autism and schizophrenia …

Objectives. These guidelines are based on a first edition that was published in 2004, and
have been edited and updated with the available scientific evidence up to October 2012 …

There is consistent evidence that brain volume changes in early and late life. Most
longitudinal studies usually only span a few years and include a limited number of …

While multiple theories have been put forth regarding the origin of schizophrenia, by far the
vast majority of evidence points to the neurodevelopmental model in which developmental …