Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

Pleiotropy and specificity: insights from the interleukin 6 family of cytokines

M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development

HY Yap, SZY Tee, MMT Wong, SK Chow, SC Peh… - Cells, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …

The role of IL-6 and IL-6 blockade in COVID-19

N Potere, A Batticciotto, A Vecchié… - Expert review of …, 2021 - Taylor & Francis
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a
dysregulated hyperinflammatory response. Areas covered Authors review evidence on IL-6 …

A review of treatment of coronavirus disease 2019 (COVID-19): Therapeutic repurposing and unmet clinical needs

PL Chen, NY Lee, CT Cia, WC Ko… - Frontiers in …, 2020 - frontiersin.org
For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

[HTML][HTML] Nanomedicine strategies to target coronavirus

MA Heinrich, B Martina, J Prakash - Nano Today, 2020 - Elsevier
With the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, the middle
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

GEDA Abuo-Rahma, MFA Mohamed, TS Ibrahim… - RSC …, 2020 - pubs.rsc.org
The global outbreak of COVID-19 viral infection is associated with the absence of specific
drug (s) for fighting this viral infection. About 10 million people are already infected, about …

Targeting inflammatory mediators in epilepsy: a systematic review of its molecular basis and clinical applications

G Costagliola, G Depietri, A Michev, A Riva… - Frontiers in …, 2022 - frontiersin.org
Introduction Recent studies prompted the identification of neuroinflammation as a potential
target for the treatment of epilepsy, particularly drug-resistant epilepsy, and refractory status …

Sarilumab administration in COVID-19 patients: Literature review and considerations

A Marino, A Munafò, E Augello, CM Bellanca… - Infectious Disease …, 2022 - mdpi.com
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection.
COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms …

Polymer nanotherapeutics: a versatile platform for effective rheumatoid arthritis therapy

R Nooreen, S Nene, H Jain… - Journal of Controlled …, 2022 - Elsevier
Rheumatoid arthritis is an aggressive and severely debilitating disorder that is characterized
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …