Targeting IL-6 trans-signalling: past, present and future prospects
S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development
HY Yap, SZY Tee, MMT Wong, SK Chow, SC Peh… - Cells, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …
The role of IL-6 and IL-6 blockade in COVID-19
N Potere, A Batticciotto, A Vecchié… - Expert review of …, 2021 - Taylor & Francis
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a
dysregulated hyperinflammatory response. Areas covered Authors review evidence on IL-6 …
dysregulated hyperinflammatory response. Areas covered Authors review evidence on IL-6 …
A review of treatment of coronavirus disease 2019 (COVID-19): Therapeutic repurposing and unmet clinical needs
For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
[HTML][HTML] Nanomedicine strategies to target coronavirus
With the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, the middle
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …
east respiratory syndrome CoV (MERS-CoV) in 2012 and the recently discovered SARS …
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
GEDA Abuo-Rahma, MFA Mohamed, TS Ibrahim… - RSC …, 2020 - pubs.rsc.org
The global outbreak of COVID-19 viral infection is associated with the absence of specific
drug (s) for fighting this viral infection. About 10 million people are already infected, about …
drug (s) for fighting this viral infection. About 10 million people are already infected, about …
Targeting inflammatory mediators in epilepsy: a systematic review of its molecular basis and clinical applications
G Costagliola, G Depietri, A Michev, A Riva… - Frontiers in …, 2022 - frontiersin.org
Introduction Recent studies prompted the identification of neuroinflammation as a potential
target for the treatment of epilepsy, particularly drug-resistant epilepsy, and refractory status …
target for the treatment of epilepsy, particularly drug-resistant epilepsy, and refractory status …
Sarilumab administration in COVID-19 patients: Literature review and considerations
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection.
COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms …
COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms …
Polymer nanotherapeutics: a versatile platform for effective rheumatoid arthritis therapy
Rheumatoid arthritis is an aggressive and severely debilitating disorder that is characterized
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …
by joint pain and cartilage damage. It restricts mobility in patients, leaving them unable to …