Atherosclerosis is one of the key problems of modern medicine, which is due to the high
prevalence of atherosclerotic cardiovascular diseases and their significant share in the …

Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by interplay
of many cellular, molecular, and genetic events that lead to excessive proliferation of …

Lung diseases with hypoxia are complicated by pulmonary hypertension, leading to heart
failure and death. No pharmacological treatment exists. Increased proinflammatory …

Mast cells are responsible for IgE-dependent allergic responses, but they also produce
various bioactive mediators and contribute to the pathogenesis of various cardiovascular …

Background Epidemiological and animal studies have associated systemic inflammation
with blood pressure (BP). However, the mechanistic factors linking inflammation and BP …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …

Pulmonary vascular remodeling and inflammation play an important role in the hypoxic-
induced lung diseases. Our previous investigations showed that peptide from yak milk …

To test the hypothesis that epoxyeicosatrienoic acids (EETs) facilitate pulmonary responses
to hypoxia, male wild-type (WT) and soluble-epoxide hydrolase knockout (sEH-KO) mice …

Epoxyeicosatrienoic acids (EET s) are cardioprotective mediators metabolized by soluble
epoxide hydrolase (sEH) to form corresponding diols (DHET s). As a sex‐susceptible target …

Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the
vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the …